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Lipo Plus

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Lipotropic Adjunct™

Lipo-Plus is a leading edge product intended for use in conjunction with a nutritious balanced diet. It provides nutrients shown to play essential roles in maintaining the health of the circulatory system. Deficiencies of the essential participants in the homocysteine cycle can contribute to the build-up of homocysteine to toxic levels. GNLD’s special formula provides balanced amounts of lipotropic factors and other nutrients known to support the healthy metabolism of homocysteine and the trasnsport and emulsification of lipids

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Lipotropic Factors

Choline
Choline is an essential water soluble nutrient, it is essential for lipid transport and metabolism, structural integrity of cell membranes, cell singaling, and as a neurotransmitter. Most of the body's choline is found in specialized fat molecules known as phospholipids, the most common of which is called phosphatidylcholine or lecithin.  

  • Structural integrity of cell membranes
    Choline is used in the synthesis of the phospholipids, phosphatidylcholine and sphingomyelin, which are structural components of human cell membranes. Sphingomyelin is an important component of the myelin sheaths of nerve cell axons.
  • Lipid transport and metabolism
    Fat and cholesterol consumed in the diet are transported to the liver by lipoproteins called chylomicrons. Once at the liver the fat and cholesterol molecules are packaged into lipoproteins called very low density lipoproteins (VLDL) for transport through the blood to tissues that require them. Choline in the form of Phosphatidylcholine is a required component of VLDL particles. Without adequate phosphatidylcholine, fat and cholesterol accumulate in the liver and can cause fatty liver disease. Choline also increases renal absorption of carnitine a compound essential in the catabolism (beta oxidation) of fats for energy (5).
  • Neurotransmitter precursor 
    Choline is a precursor for acetylcholine, an important neurotransmitter involved in muscle control, memory, and many other functions.
  • Major source of methyl groups
    Choline can be oxidized in the body to form a metabolite called betaine. Betaine is a source of methyl (CH3) groups required for methylation reactions. Methyl groups from betaine may be used to convert homocysteine tomethionine. Elevated levels of homocysteine in the blood have been associated with increased risk of cardiovascular diseases (1). Mehtly group transfer (Methylation )are also involved in gene expression and act as on off switches, Incomplete DNA methylation may lead to genetic instability, senescence (biological ageing), and cancer (8)

 

Inositol
Inositol is a type of sugar related to glucose. It occurs naturally in the body and  is found naturally in nuts, beans, melons and orange.s Inositol has potent lipotropic effects and like choline is a component of the phospholipids (Phosphatidylinositol ) in cell membranes helping with the emulsification and transport of lipids.

Inositol also acts as an antioxidant and can help reduce the oxidation of LDL cholesterol which contributes to Atherosclerosis and plaque formation. Inositol can be converted to niacin which has potent pro circulatory effects, it down regulates endothelial adhesion molecules in the blood vessels which bind pro inflammatory proteins, this down regulation results in atherosclerotic stabilization and anticlotting effects (3).

Inositol is essential for cellular communication and signalling by its role in the 2nd messenger system, it especially important in the nervous system and has been used as a treatment for mental disorders such as anxiety and depression (4)

Betaine Hydrochloride
As discussed above in choline, betain is a rich source of methyl groups (CH3) which participate in the conversion of homocysteine to methionine protecting against cardiovascular disease (6), methyl groups are important in gene expression and regulation. Betaine is a lipotrope; something that prevents or reduces accumulation of fat in the liver and also protects the liver against toxins such as those contained in bacteria ( lipopolysaccharides) and medications like Methotrexate (used in chemotherapy)(7). Betaine Hydrochloride helps with B12 absorption by decreasing pH thus helping to activate intrinsic factor which is necessary for B12 absorption.

Citrus Bioflavonoids (Hesperidin)
Hesperidin helps protect against blood vessel disorders including fragility and permeability complaints resulting in easy bruising and varicosities. This protective ability is believed to be its inhibitory effect on the action of hyaluronidase, an  enzyme that accentuates capillary permeability and fragility(9). Hesperidin in vitro and animal studies possess potent anti-inflammatory properties especially in colitis. (10)

References 

  1. Gerhard GT, Duell PB. Homocysteine and atherosclerosis. Curr Opin Lipidol 1999;10(5):417-428.  (PubMed)

  2. http://www.nrjournal.com/article/S0271-5317(02)00420-7/abstract

  3. Wu, BJ; Yan, L; Charlton, F; Witting, P; Barter, PJ; Rye, KA (2010). "Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids". Arteriosclerosis, thrombosis, and vascular biology 30 (5): 968–75. doi:10.1161/ATVBAHA.109.201129. PMID 20167660.

  4. http://www.ncbi.nlm.nih.gov/pubmed/9169302

  5. http://www.journals.elsevierhealth.com/periodicals/ntr/article/
    PIIS0271531702004207/abstract

  6. Alfthan G, Tapani K, Nissinen K, et al. The effect of low doses of betaine on plasma homocysteine in healthy volunteers. Br J Nutr. 2004;92:665-9 

  7.  Stuart AS Craig. Betaine in human nutrition. Am J Clin Nutr September 2004 vol. 80 no. 3 539-549

  8.  Cooney CA. Are somatic cells inherently deficient in methylation metabolism? A proposed mechanism for DNA methylation loss, senescence and aging.

  9. A Garg, S Garg, L Zaneveld, A Singla1. Chemistry and Pharmacology of The Citrus Bioflavonoid Hesperidin. PHYTOTHERAPY RESEARCH Phytother. Res. 15, 655–669 (2001)

  10.  Xu L, Yang ZL, Li P, Zhou YQ. Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium. Phytomedicine. 2009 Oct;16(10):989-95. doi: 10.1016/j.phymed.2009.02.021. Epub 2009 Apr 21.

 

 

 

 

Lipotropic factors, choline and inositol help keep lipids (fats) emulsified in the bloodstream and help reduce the buildup of unwanted fat in the liver. Folic acid, B6 and B12 promote proper metabolism of homocysteine, which supports a healthy antioxidant response to LDL cholesterol, free flowing circulation and overall arterial wall health.

Concentrated formula of lipotropic factors provides nutritional assistance in the mobilisation and utilisation of dietary fats.

Complete formula includes choline, inositol, betaine, folic acid, and vitamins B6 and B12; all are nutrients which support the body's own synthesis of lipotropic factors and are key elements for the proper metabolism and elimination of homocysteine, a potent oxidant.

Enhanced vitamin B12 digestion and bioavailability is provided by natural betaine.

Support for proper capillary function, important for carrying blood lipids throughout body tissues, is provided by citrus bioflavonoids and hesperidin from grapefruit.

Store below 30 degrees Celsius in a dry area away from direct heat and light.

Always read the label. Use only as directed, unless under the advice of your health care professional.

Lipo-Plus complements a balanced diet.

Lipo Plus
Lipo Plus

$70.97 NZD

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